Concussion Clinical Trial
Official title:
Aerobic Training for Management of Post-Concussion Syndrome in Adolescents
Sports-related concussions are common in adolescent-athletes. Prolonged recovery after concussion or post-concussion syndrome (PCS) is a public health problem. This project will determine the effectiveness of an aerobic exercise program for management of PCS and it will evaluate the influence of exercise on biologic correlates of PCS.
Concussion or mild traumatic brain injury (mTBI) is a public health problem and it is imperative that efficacious treatment protocols be developed to reduce the morbidity associated with PCS in adolescents. In adolescent athletes, timely return of normal neurocognitive function and return to sports safely is critical to normal development. The proposed study will fill a critical gap by systematically evaluating the potential efficacy of an aerobic training intervention for management of PCS in adolescents. To our knowledge, this will be the first randomized controlled study to evaluate the efficacy of aerobic training for treatment of PCS in adolescents as soon as four weeks after injury. The study will also improve our understanding of the pathophysiology of PCS and the biologic influence of aerobic training on PCS. The proposed study will fill a critical gap and inform the development of larger studies to assess the efficacy, and if proven efficacious, optimize the timing and intensity of aerobic training treatment protocols, thus transforming the care and limiting the adverse public impact of this condition. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03304327 -
Mindfulness and Yoga Training for Athletes With Concussion (MYTAC)
|
N/A | |
Completed |
NCT05562544 -
EEG Diagnostic for Repetitive Sub-concussive Head Impacts
|
||
Terminated |
NCT02988609 -
Concussion in Rugby Players: a Pilot Study of Neural Recovery Using fMRI
|
N/A | |
Completed |
NCT02710123 -
Sub-Threshold Exercise Treatment for Adolescents With Sports Related Concussion
|
N/A | |
Terminated |
NCT02100150 -
A Safety and Efficacy Study of NNZ-2566 in Patients With Mild Traumatic Brain Injury (mTBI)
|
Phase 2 | |
Active, not recruiting |
NCT01874847 -
PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin
|
Phase 2/Phase 3 | |
Completed |
NCT01903525 -
DHA For The Treatment of Pediatric Concussion Related to Sports Injury
|
Phase 1 | |
Completed |
NCT02262507 -
Concussion Device Audiological Measures
|
N/A | |
Enrolling by invitation |
NCT05948501 -
The Effects of Concussion on Gait and Posture in Individuals With Peripheral Vision Loss
|
||
Withdrawn |
NCT02643836 -
Pulsed Electromagnetic Field (PEMF) Therapy for Post-Concussive Syndrome
|
N/A | |
Recruiting |
NCT03360786 -
Primary Prevention of Concussion in Youth Ice Hockey Players
|
N/A | |
Recruiting |
NCT03710109 -
Evaluation of an EEG Based Concussion System
|
||
Not yet recruiting |
NCT02930395 -
Blood Biomarkers for the Management of Concussion in Professional Rugby Players
|
N/A | |
Completed |
NCT02278029 -
Driving Performance of Teenage Patients With mTBI: a Longitudinal Assessment
|
N/A | |
Completed |
NCT02268240 -
Care for Post-Concussive Symptoms
|
N/A | |
Completed |
NCT02271451 -
Q-collar and Brain Injury Biomarkers
|
N/A | |
Completed |
NCT02268058 -
Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
|
N/A | |
Active, not recruiting |
NCT03608722 -
Video Games to Track Cognitive Health
|
N/A | |
Completed |
NCT02660164 -
A Study to Assess the Effectiveness of the Nautilus BrainPulseâ„¢ as an Aid in the Diagnosis of Concussion
|
||
Completed |
NCT02556177 -
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
|
N/A |