Compare Serum Level of Klotho in Patients on Oral Antidiabetic Treatment Clinical Trial
Official title:
Serum Klotho Level in Patients on Oral Antidiabetic Treatment
Klotho is a protein found in serum, kidney,heart,brain and in other tissues,it has many functions,it is viewed as the anti aging hormone. Aging kidneys are characterized by progressive scarring and measurable declines in renal function
Objectives To study serum klotho level among diabetic patients attending diabetes and
endocrine clinic in Fayoum university on oral antidiabetic treatment
Study Design:
This study will be an observational prospective cohort study. The study duration will be 2
months.
Study Methods:
- Population of Study
- Group 1 :compare serum klotho levels in patients taking glimeperirde versus levels in
patients taking metformin
- Group 2 : compare serum klotho levels in patients taking glimeperirde versus levels in
patients taking linagliptin
- Group 3 : compare serum klotho levels in patients taking glimeperirde versus levels in
patients taking impaglifluzin
- Inclusion Criteria :
- Group 1 :Diabetics candidate for oral treatment
- Group 2 :Diabetics candidate for oral treatment
- Group 3 :Diabetics candidate for oral treatment
- Exclusion Criteria :
Diabetics candidate for insulin treatment
There will be three arms to this study; the first arm will enroll patients on glimepiride and
patients on metformin to compare serum klotho levels. The second arm will enroll patients on
glimepiride and patients on linagliptin to compare serum klotho levels. The third arm will
enroll patients on glimepiride and patients on impaglifluzin to compare serum klotho levels
Each arm will enroll 40 patients, 20 patients on glimiperide treatment,20 patient will on the
other drug,patients will be selected from Fayoum university diabetes and endocrine clinic
Data collection:
Patients will be subjected to; full clinical examination,waist hip ratio assessment,BMI
assessment fasting blood glucose,2PP blood glucose,HbA1C, urea, creatinine, uric acid total
calcium,albumin, phospherus, estimated GFR, ACR, total cholesterol, triglycerides, serum
klotho, FGF 23 levels assessment , also fracrtional excretion of phospherus will be assessed.
Control of blood glucose will be done along the period of the study. At the end of the 2
months,reassessment of the above mentioned parameters will be done.
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