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Shortened Antibiotic Treatment of 5 Days in Community-Acquired Pneumonia — CAP5  

Community-acquired Pneumonia Clinical Trial

Official title:
Shortened Antibiotic Treatment in Community-Acquired Pneumonia: A Nationwide Danish Randomized Controlled Trial

Clinical Trial Summary

CAP5 is an investigator-initiated multicentre non-inferiority randomized controlled trial which aims to assess the efficacy and safety of shortened antibiotic treatment duration of community-acquired pneumonia (CAP) in hospitalized adult patients based on clinical stability criteria. Five days after initiation of antimicrobial therapy for CAP, participants are randomized 1:1 to parallel treatment arms: 5 days (intervention) or minimum 7 days (control) of antibiotic treatment. The intervention group discontinues antibiotics at day 5 if clinically stable and afebrile for at least 48 hours. The control group receives antibiotics for a duration of 7 days or longer at the discretion of the treating physician. The primary outcome is 90-day readmission-free survival which will be tested with a non-inferiority margin of 6%.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04089787
Study type Interventional
Source Hvidovre University Hospital
Contact Simone Bastrup Israelsen, MD
Phone +45 40335495
Email simone.elisabeth.bastrup.israelsen.02@regionh.dk
Status Recruiting
Phase Phase 4
Start date September 18, 2019
Completion date June 1, 2024
View Details
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