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Colorectal Polyp clinical trials

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NCT ID: NCT06193356 Not yet recruiting - Colorectal Cancer Clinical Trials

Detection of Endoscopic Resection Scars and Delineation of Recurrence is Trainable

SCAR
Start date: July 2024
Phase: N/A
Study type: Interventional

Colorectal cancer is prevented by colonoscopy and polypectomy. Failure to recognize the endoscopic resection scar after Endoscopic Mucosal Resection (EMR) risks unrecognized recurrent or residual adenoma (RRA), which may propagate into post-colonoscopy colorectal cancer. Expert series suggest scar recognition and interrogation is well performed with a high negative predictive value of endoscopic imaging vs histopathology. In this study the authors will investigate the performance of endoscopic imaging in detecting RRA at an endoscopic resection scar amongst general endoscopist and the impact of a learning intervention on recognition of RRA.

NCT ID: NCT06067620 Not yet recruiting - Colorectal Cancer Clinical Trials

Robotic Right Hemicolectomy Versus Laparoscopic Right Hemicolectomy

PRORHEM
Start date: August 1, 2024
Phase: N/A
Study type: Interventional

Robotic right hemicolectomy with intra-corporeal anastomosis may have better short-term recovery outcomes and decreased incidence of incisional hernia when compared to the laparoscopic actual standard of care, for similar safety outcomes.

NCT ID: NCT05776381 Not yet recruiting - Colorectal Cancer Clinical Trials

The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp

Start date: September 1, 2024
Phase: Phase 2
Study type: Interventional

Management of unexpected malignant colorectal polyps removed endoscopically can be challenging due to the risk of residual tumor and lymphatic spread. International studies have shown that in patients choosing surgical management instead of watchful waiting, 54-82% of bowel resections are without evidence of residual tumor or lymphatic spread. As surgical management entails risks of complications and watchful waiting management entails risks of residual disease or recurrence, a clinical dilemma arises when choosing a management strategy. Shared decision making (SDM) is a concept that can be used in preference sensitive decision making to facilitate patient involvement, empowerment, and active participation in the decision making process. This is a clinical multicenter, non-randomized, interventional phase II study involving Danish surgical departments planned to commence in the first quarter of 2024. The aim of the study is to examine whether shared decision making and using a patient decision aid (PtDA) in consultations affects patients' choice of management compared with historical data. The secondary aim is to investigate Patient Reported Experience Measures (PREMs) and Patient Reported Outcome Measures (PROMs) using questionnaire feedback directly from the patients.

NCT ID: NCT05636085 Not yet recruiting - Colorectal Cancer Clinical Trials

Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma

reconAAsense
Start date: June 1, 2023
Phase:
Study type: Observational

This study is to determine how the Mainz Biomed Colorectal Cancer Screening Test works when used in people aged ≥45 years of age and at an average risk of developing colorectal cancer.

NCT ID: NCT05545189 Not yet recruiting - Colorectal Polyp Clinical Trials

Polyp Histology Prediction by Artificial Intelligence

Start date: October 31, 2022
Phase:
Study type: Observational [Patient Registry]

We have been developing artificial intelligence based polyp histology prediction (AIPHP) method to classify Narrow Band Imaging(NBI) colonoscopy images to predict the hyperplastic or neoplastic histology of polyps. We plan to study colonoscopy polyp samples taken by polypectomy from 1200 patients.The documented NBI still images will be analyzed by the AIPHP method and by the NICE classification parallel.Our aim is to analyze the accuracy of AIPHP and NBI classification based histology predictions and also compare the results of the two methods.

NCT ID: NCT05489380 Not yet recruiting - Colorectal Polyp Clinical Trials

Optical Diagnosis Versus Laser Measurement of Polyps' Size During Colonoscopy and Implications for Surveillance

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

Recent updates of the guidelines on polyp surveillance of the American Society of Gastrointestinal Endoscopy (ASGE) and European Society of Gastrointestinal Endoscopy (ESGE) increasingly focus on size of polyps as an important indicator of malignant transformation to colorectal cancer (CRC). However, the interobserver variability in polyp size assessment between optical diagnosis of endoscopists and pathologists is considerable. This may lead to incorrect surveillance intervals in patients at risk for developing colorectal cancer, which may increase the risk of post-colonoscopy CRC (PCCRC). This study aims to assess the precision of a new laser-based measurement system (AccuMeasure, VTM Technologies Ltd.) for polyps during colonoscopy.

NCT ID: NCT05250518 Not yet recruiting - Colorectal Polyp Clinical Trials

Argon Plasma Coagulation and Clip for the Prophylaxis of Post-polypectomy Bleeding After Hot Snare Polypectomy

APC?HSP
Start date: March 2022
Phase: N/A
Study type: Interventional

Discuss the efficacy and safety of argon plasma coagulation (APC)in comparison with clip closure for preventing colorectal post-procedure bleeding(PPB) after hot snare polypectomy(HSP); analyze the risk factors and the cost-effectiveness of bleeding prophylaxis strategies with Decision Tree Analytical Method.

NCT ID: NCT05203978 Not yet recruiting - Clinical trials for Colorectal Neoplasms

Virtual Reality Colonoscopy : a Study From Nancy

Start date: March 2022
Phase:
Study type: Observational

Colonoscopy is an exam which can be responsible for pain and discomfort for the patient. Therefore colonoscopy is performed most of the time under general anaesthesia. Moreover, drug-induced sedation comes with adverse effects especially among fragile patients. Besides, monitoring patients during and after sedation is both logistically demanding and costly. Virtual reality offers immersive and three dimensional experiences that distract the attention and might improve patients comfort. The aim of the study is to investigate the use of virtual reality during colonoscopy versus general anaesthesia.

NCT ID: NCT05064124 Not yet recruiting - Colorectal Polyp Clinical Trials

Early diAgnosis Real-Time Healthcare System for CANcer Trial

EARTHSCAN
Start date: June 2024
Phase:
Study type: Observational

The purpose of the study is to assess whether the AI characterisation system of the CADDIE device improves the endoscopists accuracy in the optical diagnosis of diminutive colorectal polyps in the bowel during colonoscopy. Participants will either have a colonoscopy with the assistance of the CADDIE device characterisation AI system ("intervention group") or have a colonoscopy in line with routine clinical practice i.e., without the CADDIE device characterisation AI system ("control group"). The randomisation method of this trial will allocate enrolled participants to the "intervention" group and to the "control" group by a technique similar to flipping a coin.

NCT ID: NCT05041478 Not yet recruiting - Colon Cancer Clinical Trials

Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas