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Clinical Trial Summary

As a good niche for bacterial growth, appendix plays a very important role in maintaining and protecting intestinal symbiotic flora. Appendectomy will lead to intestinal microecological disorders. Therefore, we put forward the hypothesis that "appendectomy leads to intestinal microecological disorders and then increases the risk of colorectal cancer". In this study, the feces of normal controls, appendectomy and patients with colorectal cancer were collected, and the specific changes of intestinal flora after appendectomy were explored in detail from the level of family, genus and species by macrogenomic sequencing. Then through functional gene analysis, metabolic pathway analysis and other methods to explore the molecular mechanism of colorectal cancer risk changes and the changes of microflora involved, and verified by mouse fecal bacteria transplantation animal experiment.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05066048
Study type Observational
Source First Affiliated Hospital Xi'an Jiaotong University
Contact Junjun She, MD,PHD
Phone 0086-18991232713
Email [email protected]
Status Recruiting
Phase
Start date April 30, 2021
Completion date January 31, 2024

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