Colorectal Neoplasms Clinical Trial
Official title:
A Randomized, Parallel-controlled, Exploratory Clinical Trial of Second-line Chemotherapy With Second-line Chemotherapy Versus Second-line Chemotherapy With Apatinib in the Treatment of Metastatic Colorectal Cancer
(1) Evaluate the efficacy of apatinib in combination with standard second-line chemotherapy for advanced colorectal cancer. Whether it can prolong Progression Free Survival (PFS), overall survival (OS) in patients with advanced colorectal cancer and reduce symptoms and improve quality of life compared with standard second-line chemotherapy; (2) Observe the safety of apatinib for the treatment of advanced colorectal cancer.
Standard second line chemotherapy includes chemotherapy based on irinotecan or chemotherapy
based on oxaliplatin.
Apatinib is a small-molecule tyrosine kinase inhibitor (TKI) that highly selectively binds to
and strongly inhibits vascular endothelial growth factor receptor 2 (VEGFR-2), with a
decrease in VEGF-mediated endothelial cell migration, proliferation, and tumor microvascular
density. A phase II trail of Apatinib has been demonstrated that Apatinib is safe to treat
the metastatic colorectal cancer and the disease control rate can reach 50%.
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