Colorectal Neoplasms Clinical Trial
Official title:
A Randomized Controlled Trial of Preoperative Carbohydrate Drinks on Postoperative Walking Capacity in Colorectal Surgery.
NCT number | NCT01844375 |
Other study ID # | SIRB050 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | May 2013 |
Est. completion date | July 2016 |
Verified date | October 2019 |
Source | Siriraj Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This prospective randomized controlled study is designed to investigate whether preoperative oral carbohydrate loading improves postoperative walking performance, a surrogate indicator for overall functional recovery, in patients undergoing colorectal surgery as measured by 2-minute and 6-minute walk test. The secondary outcomes are postoperative insulin resistance measured with plasma insulin and glucose concentrations. The tertiary outcomes are duration of hospital stay, patients satisfaction during staying in the hospital and morbidity measured as postoperative complications.
Status | Completed |
Enrollment | 70 |
Est. completion date | July 2016 |
Est. primary completion date | July 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - patients aged greater than 18 years undergoing elective colorectal surgery at Siriraj Hospital Exclusion Criteria: - diabetes mellitus - any endocrine disorders or metabolic abnormalities - impaired renal function (GFR <60 ml/min) - impaired hepatic function (Child-Pugh score class C) - a history of delayed gastric emptying time - body mass index >30 - inability to communicate - severe physical disability. |
Country | Name | City | State |
---|---|---|---|
Thailand | Siriraj hospital | Bangkok |
Lead Sponsor | Collaborator |
---|---|
Mingkwan Wongyingsinn, MD |
Thailand,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Meters Walked During 2-Minute Walk Test | Primary outcomes are 2-minute walk test (2MWT) which will be measured before surgery to be a baseline, and then 2MWT will be measured at 72 hours after surgery. Patients will be asked to walk back and forth along a 15 m stretch of hallway as much as they can over a period of 2 minutes. To ensure safety, the evaluator walks behind the patient. Patients are told that they can rest if necessary, and they are allowed to use their regular walking aids. Any intravenous lines, tubes, or infusion pumps will be attached to a pole and pushed by the patient. The walking distance will be recorded in meters. If the patient is unwilling or unable to walk, the reason will be recorded and the distance '0' will be recorded for that day. | 72 hours after surgery | |
Secondary | Change of Serum Glucose Concentration | Serum glucose concentrations will be measured preoperatively, and on the 24 hour postoperatively. | Baseline and postoperative 24 hours | |
Secondary | Nitrogen Balance | 24-hour urine urea nitrogen was measured on the postoperative day 3. The urine samples during 24 hours on the postoperative day 3 were centrifuged (Cobas 8000 Modular Analyzer Series; Modular Pre-analytics Evo, Roche) at 3000 rpm for 5 min at 22.5°C, and measured using a urease/glutamate dehydrogenase coupled enzymatic technique (Cobas 8000 Modular Analyzer Series: C 702 Module, Roche). The nitrogen balance was calculated by measuring urinary urea nitrogen and dietary nitrogen intake during the same 24-hour period. The nitrogen intake was estimated for each patient following a doctor's diet order and types of food formulas in hospital, and then dividing the daily protein intake by 6.25. The urine urea nitrogen was added by 4 to account for non-urinary losses of nitrogen |
on the postoperative day 3 |
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