Clinical Trials Logo

Colorectal Neoplasm clinical trials

View clinical trials related to Colorectal Neoplasm.

Filter by:

NCT ID: NCT02758951 Recruiting - Colorectal Cancer Clinical Trials

Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases

CAIRO6
Start date: June 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

This is a multicentre, open-label, parallel-group, phase II-III, superiority study that randomises patients with isolated resectable colorectal peritoneal metastases in a 1:1 ratio to receive either perioperative systemic therapy and cytoreductive surgery with HIPEC (experimental arm) or upfront cytoreductive surgery with HIPEC alone (control arm).

NCT ID: NCT01542281 Recruiting - Colorectal Neoplasm Clinical Trials

Pre-habilitation to Improve Outcomes in Patients Undergoing Liver Resection for Cancer

Start date: January 2012
Phase: N/A
Study type: Interventional

1. To determine whether a combined nutritional support program and exercise-based prehabilitation is superior to nutritional support alone in increasing functional recovery and reducing post-operative morbidity after surgery for HPB malignancy. 2. To understand which measures of immediate surgical recovery are sensitive to prehabilitation interventions and predict change in later outcome measures.

NCT ID: NCT01310478 Recruiting - Colorectal Neoplasm Clinical Trials

Recombinant Human Endostatin in Combination With mFOLFOX6 in Patients With Metastatic Colorectal Cancer

Start date: August 2010
Phase: Phase 1
Study type: Interventional

To investigate safety and tolerance of dose-escalation of infusional recombinant human endostatin in combination with mFOLFOX6 as initial therapy for patients with metastatic colorectal cancer.

NCT ID: NCT00745927 Recruiting - Colorectal Cancer Clinical Trials

Application of CO2 Insufflations in Colonoscopy Randomized Trial

Start date: June 2008
Phase: N/A
Study type: Interventional

It has been reported that carbon dioxide (CO2) insufflation can reduce patient pain and abdominal discomfort during and after colonoscopy. Its safety and efficacy during colonoscopy even under sedation has been already assessed in some earlier trials. Air insufflation is still the standard method, however, because of a lack of suitable equipment and continued technical improvement in colonoscopy. In laparoscopic surgery, CO2 insufflation is widely applied and safely used with the patient under general anesthesia. CO2 insufflation is also applied for CT colonography for reduction of discomfort during or after procedure.2 During endoscopic procedure for colorectal neoplasia resection, however, long procedural time may increase not only the degree of discomfort during and after the procedure but also the risk of perforation. In addition to laparoscopic surgery, CO2 insufflation has also been applied to other endoscopic procedures. Saito et al reported the application of CO2 insufflation in Endoscopic submucosal dissection (ESD) of colorectal neoplasia in a prospective study in which their average procedural time using CO2 insufflation was 90 minutes under conscious sedation with average of 5.6 mg of midazolam. When compared with control group using room air, statistically negligible difference of pCO2 was observed with significant difference in abdominal discomfort.6 Screening colonoscopy, which can be completed within 15 minutes if no lesion being detected, requires high screenee satisfaction so as to improve patient compliance. In the setting of colonoscopy after positive FOBT, the attendance rate for secondary colonoscopy was around 60 to 70 % according to the data demonstrated in previous RCT and population-based studies. With application of CO2 insufflation, further improvement of patient compliance can be anticipated. This study aims to investigate whether use of CO2 insufflations can reduce examinee discomfort in comparison with air.