PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for

Status Not yet recruiting

Clinical Trial Summary

Clinical Trial Description

The purpose of this study is to preliminarily observe the efficacy and safety of PCSK9 inhibitors in combination with standard advanced first-line regimens in the treatment of advanced colorectal cancer with pMMR/MSS. To evaluate progression-free survival (PFS) after PCSK9 inhibitor combination, overall survival (OS) after PCSK9 inhibitor combination, and to evaluate the safety and tolerability of PCSK9 inhibitor combination therapy based on NCI-CTCAE version 4.03, and to further explore efficacy predictive biomarkers based on changes in the expression of specific immune markers in blood and tissue specimens at baseline and after treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06391905
Study type	Interventional
Source	Guangdong Provincial People's Hospital
Contact	YONG LI, Doctor
Phone	13822177479
Email	liyong@gdph.org.cn
Status	Not yet recruiting
Phase	Phase 2
Start date	May 6, 2024
Completion date	May 6, 2028

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PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms