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NCT06319404 Clinical Trial

Immune Function of Colorectal Cancer Lymph Nodes

Colorectal Cancer Clinical Trial

Official title:
A Multiomics-based Study of the Immune Function of Colorectal Cancer Lymph Nodes

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06319404
Other study ID # 2022YFC2505700
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date April 1, 2024
Est. completion date April 1, 2026

Study information
Verified date January 2024
Source Shanxi Province Cancer Hospital
Contact Xu Guan
Phone 13141307719
Email drguanxu@163.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 500
Est. completion date April 1, 2026
Est. primary completion date April 1, 2026
Accepts healthy volunteers
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria: - Stage I-III colorectal cancer patients undergoing radical surgery - Complete imaging, pathology and genetics multi-omics data available - 18-75 years old Exclusion Criteria: - Patients with preoperative neoadjuvant therapy - Patients with incomplete clinical information - Patients with other malignant tumors - Patients with acute infections or untreated chronic infections

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (3)
Lead Sponsor Collaborator
Shanxi Province Cancer Hospital Cancer Institute and Hospital, Chinese Academy of Medical Sciences, The Second Affiliated Hospital of Harbin Medical University

Outcome
Type Measure Description Time frame Safety issue
Primary To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them 2024.04-2026.04
Primary To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways 2024.04-2026.04
Primary The immune function of tumor draining lymph nodes of colorectal cancer patients was previously identified based on radiomics Preoperative imaging data (CT, MRI) of patients were collected, and information in the images was extracted based on artificial intelligence algorithms. Predictive models were constructed to identify patients with good or bad immune function before surgery and guide subsequent treatment 2024.04-2026.04
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