Prognosis Stratification for pT4bN0M0 Colorectal Cancer Following Multivisceral Resection

Colorectal Cancer Clinical Trial

Official title:

Prognosis Stratification for pT4bN0M0 Colorectal Cancer Following Multivisceral Resection: A Multi-institutional Retrospective Analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06115837
• Other study ID #: NCC2330
• Status: Completed
• Start date: September 1, 2023
• Est. completion date: September 26, 2023

Study information

• Verified date: October 2023
• Source: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study was to identify the prognostic factors of affecting pT4bN0M0 colorectal cancer patients, so as to better stratify the prognostic differences among patients with the same stage.

Description:

Patients with pT4b stage colorectal cancer (CRC) are a complex and special group due to the diversity of infiltrated organs, patients with the same stage often have different prognosis after multivisceral resection (MVR), some important prognostic factors have not been deeply explored, and additional prognostic factors are needed to improve the survival assessment of these patients. In this study, investigators attempted to evaluate the prognostic factors of pT4bN0M0 colorectal cancer, and then stratify the prognosis of such patients to distinguish the survival differences among different patients.

This study was a multicenter retrospective cohort study based on a multicenter database which contained hospitalization.The prognostic factors of pT4bN0M0 colorectal cancer patients were analyzed, and the prognostic grading system was constructed to accurately stratify the survival of pT4bN0M0 patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 172
• Est. completion date: September 26, 2023
• Est. primary completion date: September 16, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 95 Years

Eligibility

Inclusion Criteria:

1. The patient was pathologically diagnosed as colorectal adenocarcinoma.

2. Patients with pT4bN0M0 colorectal cancer.

3. Patients with R0 resection.

Exclusion Criteria:

1. Patients with distant metastasis.

2. Patients with R1 or R2 resection.

3. Patients with lymph node metastasis

4. Recurrent colorectal cancer.

Related Conditions & MeSH terms

• Colorectal Cancer
• Colorectal Neoplasms

Intervention

Procedure:
• multivisceral resection
The prognostic factors were analyzed for pT4bN0M0 colorectal cancer after multivisceral resection

Locations

Country	Name	City	State
China	Cancer Hospital Chinese Academy of Medical Sciences	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Overall survival	Overall survival is defined as the time from the surgery to death or last follow-up, regardless of disease recurrence, which was measured in months.	The endpoint of the overall survival assessment is the last follow-up or patient death. Follow-up time is up to 72 months.
Primary	Cancer specific survival	Cancer specific survival is defined as the time from the diagnosis to death due to cancer progression, which was measured in months.	The endpoint of the cancer specific survival assessment is the patient death due to cancer. Follow-up time is up to 72 months.