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Clinical Trial Summary

This is a multicenter, open-label, parallel-group, randomised, A phase IIb clinical trial of efficacy and safety of Ametumumab in combination with anti-PD-1 monoclonal antibody and FOLFIRI versus Ametumumab or Cetuximab in combination with FOLFIRI in patients with RAS wild-type advanced colorectal cancer.


Clinical Trial Description

This is a multicenter, open-label, parallel-group, randomised, phase IIb trial. This study is to evaluate and compare the efficacy and safety of Ametumumab (anti-EGFR monoclonal antibody) combined with anti-PD-1 monoclonal antibody in first-line treatment of RAS wild-type colorectal cancer patients, as well as to assess the immunogenicity and pharmacokinetic profile and recommend dosing regimen for phase III clinical trials.Conditions and keywords. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05684211
Study type Interventional
Source Shanghai Celfuture Biotech Co., Ltd.
Contact kongli Zhu, Master
Phone 15800363686
Email tsl-zukongli@tasly.com
Status Not yet recruiting
Phase Phase 2
Start date January 2023
Completion date January 2023

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