Colorectal Cancer Clinical Trial
Official title:
Postoperative Oral and Intestinal Flora Changes in Patients With Colorectal Cancer and the Relationship Between These Changes and Prognosis
Specific oral microbiome has been found to contribute to the development of colorectal cancer. We speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment. This study aim to discover if any difference of oral microbiota exist in patients who suffer from cancer relapse compared with patients who do not. Finally develop patient-centred programmes of surveillance protocols base on microbiota analysis.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | March 1, 2021 |
Est. primary completion date | November 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Requirements of informed consent and assent of participant, parent or legal guardian as applicable - Patients who underwent exhaustive colorectal cancer surgical resection and accept colonoscopy - Patients between the age of 35 and 75 years old without considering sex - Patients with BMI= 18.5-23.9 - Participants can follow the visit plan Exclusion Criteria: - Patients with colorectal cancer with distant metastasis - Chronic renal diseases and hepatic cirrhosis - Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months - Individuals with a history of Chronic diarrhea - Individuals with a history of Diabetes mellitus - Individuals with a history of Hypertension - Individuals with a history of autoimmune diseases - Use of antibiotics and probiotics 3 mouth before samples collection - Individuals with a history of abdominal operation due to any reason - Individuals with any history of cancer other than colorectal cancer - Individuals with Inflammatory bowel disease |
Country | Name | City | State |
---|---|---|---|
China | Yunwei Wei | Harbin | Heilongjiang |
Lead Sponsor | Collaborator |
---|---|
First Affiliated Hospital of Harbin Medical University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Colorectal cancer or adenoma recurred | Use colonoscopy to check for recurrence of colorectal cancer | 12 months after surgery |
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