Colorectal Cancer Clinical Trial
Official title:
Prognostic Value of Disseminated Tumour Cells in Bone Marrow in Patients With Left-sided Colorectal Cancer.
NCT number | NCT03640572 |
Other study ID # | DCT LSCC |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | June 1, 2007 |
Est. completion date | December 30, 2018 |
Verified date | February 2019 |
Source | Jagiellonian University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Two metaanalyses of studies on the prognostic significance of circulating cancer cells in
colorectal cancer indicated, that the presence of circulating tumour cells (CTC) in the
peripheral blood is the negative prognostic factor. However there is no sufficient evidence
that disseminated tumour cells (DTC) in the bone marrow of the colorectal cancer patients
influence the prognosis. There is the evidence that right-sided and left- sided cancers may
have different biology and different prognosis. Therefore in this study the investigators
concentrated on the left colon and rectum locations with the locally advanced cancer being
the main area of interest.
The aim of this study was to analyse the relation of DTC with the tumor characteristics,
cancer progression and survival in left sided colorectal cancer.
Status | Completed |
Enrollment | 91 |
Est. completion date | December 30, 2018 |
Est. primary completion date | December 31, 2012 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - age > 18 years - histologically proven left-sided colorectal cancer - signed informed consent Exclusion Criteria: - synchronous right sided colon cancer - history of other neoplasm - inability to understand and sign informed consent |
Country | Name | City | State |
---|---|---|---|
Poland | 1st Department of General Surgery | Kraków | Malopolska |
Lead Sponsor | Collaborator |
---|---|
Jagiellonian University |
Poland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Overall survival (OS) | OS in patients with and without DTC in bone marrow | 5 years | |
Secondary | Local recurrence rate | Local recurrence in patients with and without DTC in bone marrow | 5 years | |
Secondary | Systemic recurrence | Systemic recurrence in patients with and without DTC in bone marrow | 5 years |
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