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A Model for the Early Diagnosis of Colorectal Cancer by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA

Colorectal Cancer Clinical Trial

Official title:
A Single-centre, Prospective Trial of the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA for Establishing a Model for the Early Diagnosis of Colorectal Cancer

Clinical Trial Summary

In this study, the investigators establish a model for the early diagnosis of colorectal cancer based on detection of 5-hydroxymethylcytosine (5-hmC) in training group and validate the effectiveness of the model using a validation group.

Clinical Trial Description

Many kinds of cancers are associated with changes in epigenetics, including 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC). This changes may help diagnose cancer. The new detection method for 5-hmC can meet the requirements of liquid biopsy.

The traditional diagnostic methods for colorectal cancer is colonoscopy and pathology which are inconvenient and unpleasant, and sometimes, it is difficult for the very patients to get tissues or get enough tissues. In addition, other screening methods for colorectal cancer,such as guaiac-based fecal occult blood testing and a blood test for methylated SEPT9 DNA, have the shortcomings of relatively low sensitivity and specificity. As a result, it is imperative to find a new detection method for early diagnosis of colorectal cancer with high the advantages of high sensitivity and specificity, minimally invasive and convenient.

The aim of this research study is to establish a model for the early diagnosis of colorectal cancer by the detection of 5-hmC in plasma cell-free DNA. Patients who are diagnosed with colorectal cancer by colonoscopy and pathology and not received any anti-tumor therapy (Arm A) will be eligible for inclusion as well as healthy individuals with normal colonoscopy (Arm B). Then, 5-hmC in plasma cell-free DNA will be detected and compared between the two arms of patients (training group) to establish a model to diagnosis other people (validation group) who may suffer from colorectal cancer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03599947
Study type Observational [Patient Registry]
Source Fudan University
Contact
Status Recruiting
Phase
Start date July 16, 2018
Completion date May 31, 2019
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