Colorectal Cancer Clinical Trial
Official title:
Structural of the Gut Mucosal Microbiota is Associated With Colorectal Cancer Relapses After Curative Surgery
Colonic microbiome has been found to contribute to the development of colorectal cancer. We speculate that gut microbiota related to colorectal cancer relapse after curative treatment. This study aim to discover if any difference of gut microbiota exist in patients who suffer from cancer relapse compared with patients who do not. Finally develop patient-centred programmes of surveillance protocols base on microbiota analysis.
Treatments for colorectal cancer of all stages have evolved considerably over the past two
decades, resulting in improved long-term outcomes. After curative treatment, however, 30% of
patients with stage I-III and up to 65% of patients with stage IV colorectal cancer develop
recurrent disease.
The human colon plays host to a diverse and metabolically complex community of
microorganisms. While the colonic microbiome has been found to contribute to the development
of colorectal cancer. Investigators speculate that gut microbiota related to colorectal
cancer relapse after curative treatment.
Patients are routinely offered surveillance in order to detect disease recurrence at an
early, asymptomatic stage, with the intention of improving survival. Nevertheless,
controversy continues to surround the optimal surveillance protocols. Investigators aim to
discover if any difference of gut microbiota is exist in patients who suffer from relapse
compared with patients who do not.
Future surveillance after colorectal cancer treatment should focus on risk-stratification and
should incorporate current knowledge on risk of recurrence in relation to the biology of the
tumour as well as gut microbiota feature. Finally investigators will develop patient-centred
programmes of surveillance protocols base on microbiota analysis.
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