Colorectal Cancer Clinical Trial
Official title:
Impact of Full-spectrum Endoscopy in Colorectal Cancer Screening: Randomized Controlled Trial
The purpose of this study is to compare the adenoma detection rates of full-spectrum endoscopy versus standard forward-viewing colonoscopy in colorectal cancer screening programme.
Colorectal cancer is the third most common neoplasia and the second leading cause of cancer
death in West countries. Colonoscopy is the gold standard for prevention of colorectal
cancer disease. Screening for colorectal cancer with biennial faecal occult blood testing is
a widely used strategy followed by colonoscopy for those with a positive test. Colonoscopy
identifies polyps during the procedure as well as polyp removal in order to prevent
progression to cancer. Although, interval cancer appears after a colonoscopy because of
22-28% of polyp missed rates. Advanced Technology may improve adenoma detection rates so
decrease interval cancer and reduce mortally. Full-spectrum endoscopy with 330º angle vision
decrease adenoma miss rate in general population.
The investigators conducted a randomized trial in patients from colorectal cancer screening
programme (aged 50-69 years) after faecal immunological test positive. One arm the
colonoscopy is performed with standard forward view colonoscopy (170º angle view) and the
other arm is performed with full-spectrum endoscopy (EndoChoice) (330º angle view)
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Screening
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