A Phase Ib Study of Fruquintinib in 3rd Line mCRC

Status Completed

Clinical Trial Summary

Fruquintinib is a novel oral small molecule compound discovered and developed by Hutchison MediPharma that selectively inhibits vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3 and has demonstrated potent inhibitory effects on multiple human tumor xenografts.Based on first-in-human study, both 4mg QD and 5mg 3wks on/1wk off are safety and efficacy, this phase Ib study is to evaluable the safety, tolerability and efficacy of these 2 regimens with mCRC failed 2nd therapy or more and to determine the recommended dose and regimen in phase II/III study.

Clinical Trial Description

This is a phase Ib, randomize, interventional, open-label, multicenter study to provide fruquintinib to subjects diagnosed with metastatic colorectal cancer who have failed after standard therapy and for whom no therapy alternatives exist.

The primary endpoint of this study will be safety. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01975077
Study type	Interventional
Source	Hutchison Medipharma Limited
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	December 2012
Completion date	October 2014

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