Colorectal Cancer Clinical Trial
Official title:
Inflammatory Response Following Colorectal Cancer Surgery Depends on the Type of Anesthesia and Surgery
Laparoscopic technique and epidural anesthesia have been proposed to improve postoperative outcome following colorectal cancer surgery. The investigators hypothesize that the inflammatory response is attenuated by laparoscopic surgery and epidural anesthesia compared to traditional open surgery under general anesthesia.
Patients scheduled for open colorectal cancer surgery were randomly allocated to receive
general anesthesia (CON group, n=22) or general anesthesia with thoracic epidural anesthesia
(EPI group, n=21). Patients undergoing laparoscopic surgery (LAP group, n=20) composed the
third arm of the study. Measurement of perioperative changes in several hormones and
cytokines were blinded to group assignment.
Primary outcome: Compare simultaneously two types of surgical and anesthesia techniques for
colorectal cancer surgery and measure to what extent the stress response is lessened.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
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