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Pharmacogenomics Study of CPT-11 as the First-line Chemotherapy for mCRC — PSIFL  

Colorectal Cancer Clinical Trial

Official title:
Genetic Variants and the Efficacy or Severe Adverse Reactions of CPT-11 Based Regimens in mCRC

Clinical Trial Summary

Irinotecan (CPT-11) is now widely used as the first-line chemotherapy for mCRC. There were 4 key enzymes for CPT-11 metabolizing, CYP3A4, UDP-glucuronosyltransferase, carboxylesterase(CES), and ATP-binding cassette (ABC) transporters. Genetic variations of those enzymes may cause the heterogeneity in safety and efficacy of CPT-11. The aim of this study is to figure out the correlation between the genetic polymorphism and the drug response.

Clinical Trial Description

collect blood samples,determining genetic contribution to the safety and efficacy of CPT-11. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01282658
Study type Observational
Source Huazhong University of Science and Technology
Contact Yuan X Lin, PHD
Phone 0086-02783663342
Email yxl@medmail.com.cn
Status Recruiting
Phase N/A
Start date November 2010
Completion date May 2013
View Details
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