Colorectal Cancer Clinical Trial
Official title:
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
1. To determine the association between LVD and clinico-pathologic variables in archived
colorectal cancer and Nasopharyngeal carcinoma specimens
2. To determine the association between VEGF-C,-D expression with COX-2 expression and
clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma
3. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma
Lymphangiogenesis and factors modulating lymphangiogenesis are associated with
clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer.
Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and
Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of
Pathology. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal
carcinoma, the investigators intend to analyze archived specimens collected in a
previously conducted study. Colorectal tumor and nodal specimens and Nasopharyngeal
carcinoma primary will be examined for MVD, LVD and growth factor expression using
established haematoxylin and eosin and immunohistochemical techniques. Quantification
of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological
variables using standardised methods.
n/a
Observational Model: Case-Crossover, Time Perspective: Cross-Sectional
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