Colorectal Cancer Clinical Trial
Official title:
Study of Biomarkers in Tissue Samples of Patients With Stage III Colon Cancer Treated With Adjuvant Chemotherapy Comprising Fluorouracil-Based Regimens(B-CAST)
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer who
have undergone surgery and chemotherapy may help doctors predict how well patients will
respond to treatment.
PURPOSE: This research study is looking at tumor samples from patients with stage III colon
cancer who have undergone surgery and chemotherapy.
OBJECTIVES:
- Identify predictive factors of efficacy and safety of adjuvant chemotherapy comprising
fluorouracil-based regimens in patients with stage III colon cancer.
- Investigate possibility of "personalized treatment" with adjuvant chemotherapy based on
the predictive factors identified.
OUTLINE: Patients' tumor tissue samples are collected for protein expression levels of
thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), VEGF, EGFR,
mRNA-expression levels of TP, DPD, thymidylate synthase (TS), and orotate phosphoribosyl
transferase (OPRT) by ELISA, Human Duo Set, and RT-PCR assays.
Patients' enzyme expression levels are compared with their clinical data.
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