Colorectal Cancer Clinical Trial
Official title:
Identification of the Prognostic Factors of Stage II Colon Cancer Patients Receiving Adjuvant Chemotherapy With UFT
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict which patients will respond to treatment.
PURPOSE: This laboratory study is looking at prognostic factors in patients receiving
tegafur-uracil for stage II colon cancer that was completely removed by surgery.
OBJECTIVES:
- Identify the prognostic factors in patients with curatively resected stage II colon
cancer receiving adjuvant chemotherapy with tegafur-uracil.
- Identify predictive factors of chemosensitivity to this regimen in these patients.
OUTLINE: Available tumor tissue samples are analyzed by real-time reverse transcriptase-PCR
for TS, DPD, TP, OPRT, VEGF, cyclooxygenase-2, and FPGS; by PCR for microsatellite
instability and genomic deletions on chromosome arm 18q; and pathologically for tumor
budding, Crohn's-like lymphoid reaction, category of extent of poor differentiation, and
fibrotic cancer stroma. The candidate prognostic and predictive markers are analyzed for
correlation with disease-free survival, relapse-free survival, and overall survival of
patients.
;
Observational Model: Cohort, Time Perspective: Prospective
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