Colorectal Cancer Clinical Trial
Official title:
Study to Analyze the Predictive Role of Factors Implicated in the Signaling Pathway of the EGFR in Response to Treatment With Neoadjuvant Chemoradiotherapy in Patients With Cancer of the Esophagus or Rectum
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how patients will respond to
treatment.
PURPOSE: This clinical trial is studying how well biological factors work in predicting
response to treatment in patients with esophageal cancer or rectal cancer.
OBJECTIVES:
Primary
- Analyze various biological factors that can be used as markers to predict response to
treatment and correlate with the signaling pathway of EGFR.
Secondary
- Establish a tissue bank to store information about the response to treatment and
survival.
OUTLINE: Patients undergo endoscopy, 11 biopsies of tumor tissue, and 3 biopsies of healthy
mucosa. Blood samples are also collected. Samples are analyzed for the expression of 4
receptors in the EGFR family, polymorphisms at intron 1 of the EGFR gene, and gene mutations
in downstream signaling pathways.
After surgery, patients are followed every 3 months.
;
Allocation: Non-Randomized, Primary Purpose: Diagnostic
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