Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Colorectal Cancer Clinical Trial

Official title:

A Phase II Study of the Rate of Conversion to Complete Resection in Patients With Initially Inoperable Hepatic-Only Metastases From Colorectal Cancer After Treatment With Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Best Systemic Chemotherapy

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT00492999
• Other study ID #: 06-075
• Secondary ID: MSKCC-06075
• Status: Active, not recruiting
• Phase: Phase 2
• Start date: May 2007
• Est. completion date: May 2025

Study information

• Verified date: May 2024
• Source: Memorial Sloan Kettering Cancer Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Hepatic arterial infusion uses a catheter to carry tumor-killing substances directly into the liver. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving floxuridine and dexamethasone directly into the arteries around the tumor together with combination chemotherapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well hepatic arterial infusion with floxuridine and dexamethasone works when given together with combination chemotherapy in treating patients with colorectal cancer that has spread to the liver.

Description:

OBJECTIVES: Primary - Assess the rate of conversion to complete resection in patients with initially unresectable colorectal cancer metastatic to the liver treated with hepatic arterial infusion comprising floxuridine and dexamethasone in combination with systemic irinotecan hydrochloride and either oxaliplatin or leucovorin calcium/fluorouracil. Secondary - Evaluate the time to progression in patients treated with this regimen. - Evaluate disease-free survival of patients treated with this regimen. - Evaluate overall survival of patients treated with this regimen. - Determine the response rate (complete, partial, and moderate response) in patients treated with this regimen. - Evaluate the safety profile and tolerability of this regimen in these patients. - Assess the expression pattern of the VEGF receptor VEGFR1, VEGFR2, and VEGFR3 and their cognate ligands (i.e., VEGF-A, VEGF-B, VEGF-C, VEGF-D, and P1GF) in patients treated with this regimen. - Correlate circulating angiogenic markers with tumor resectability, disease progression, and patient survival. - Procure normal and diseased liver tissue for evaluation of thymidylate synthase, p53 gene, p21, topoisomerase 1, dihydropyrimidine dehydrogenase, and excision repair cross-complementing gene levels. - Assess the expression pattern of tissue factor (TF) and explore its correlation with the TF receptors PAR-1, PAR-2, TF regulators PTEN, k-ras, b- raf, p53, and outcome.(Closed as of 11/30/10) - Assess the prognostic and predictive role of preoperative, pretreatment, and during treatment serum TF in regards to outcome (progression-free survival and overall survival) and response to treatment with this regimen and to salvage treatments such as EGFR-inhibitors.(Closed as of 11/30/10) OUTLINE: This is an open-label, nonrandomized study. Patients are assigned to 1 of 2 treatment groups according to receipt of more than 2 prior courses of oxaliplatin (no vs yes). - Group 1 (no more than 2 prior courses of oxaliplatin): Patients receive hepatic arterial infusion (HAI) therapy comprising floxuridine and dexamethasone continuously on days 1-14. Patients also receive oxaliplatin IV over 2 hours and irinotecan hydrochloride IV over 30 minutes on days 1 and 15. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. - Group 2 (more than 2 prior courses of oxaliplatin): Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. In both groups, patients may undergo complete resection of liver metastases after completion of at least 3 courses of therapy. Some patients undergo blood and tissue collection periodically for correlative and immunological studies. Samples are analyzed for VEGF receptor VEGFR1, VEGFR2, VEGFR3, thymidylate synthase, p53, p21, topoisomerase 1, dihydropyrimidine dehydrogenase, and excision repair cross-complementing gene levels. After completion of study treatment, patients are followed every 3 months for 2 years, every 4 months for 3 years, and then annually thereafter.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 64
• Est. completion date: May 2025
• Est. primary completion date: May 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 120 Years

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed colorectal adenocarcinoma metastatic to the liver
• Previously treated or untreated disease
• No clinical or radiographic evidence of extrahepatic disease
• Primary tumor may be present at study registration provided it is not obstructing the intestinal lumen or is significantly bleeding
• If present, the primary tumor will be resected at the time of pump placement
• Must have inoperable liver metastases confirmed by 2-3 hepatobiliary surgeons and the assigned radiologist
• Liver metastases < 70% of the liver parenchyma
• Inoperable liver metastases is defined by one of the following:
• More than 6 metastases in a single lobe with one lesion = 5 cm
• At least 6 metastases distributed diffusely in both lobes of the liver
• When a margin-negative resection would require resection of all three hepatic veins, both portal veins, or the retrohepatic vena cava
• Requires a resection that leaves < 2 hepatic segments (not including the caudate lobe) behind with adequate arterial or portal inflow, venous outflow, and biliary drainage
• No ascites or hepatic encephalopathy
• No history of primary CNS tumors

PATIENT CHARACTERISTICS:

• Karnofsky performance status 60-100%
• WBC = 3,000/mm^3
• ANC = 1,500/mm^3
• Platelet count = 100,000/mm^3
• INR < 1.5
• Hemoglobin = 9 g/dL
• Creatinine = 1.5 mg/dL
• Total bilirubin = 1.5 mg/dL
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Physically able to tolerate major partial hepatectomy
• No active infection
• No concurrent active malignancies, except potentially resectable primary colorectal tumor
• No bleeding diathesis or coagulopathy
• No history of serious systemic disease, including any of the following:
• Myocardial infarction within the past 6 months
• Uncontrolled hypertension (i.e., blood pressure > 150/100 mm Hg on medication)
• Unstable angina
• New York Heart Association class II-IV congestive heart failure
• Unstable symptomatic arrhythmia requiring medication
• Chronic atrial arrhythmia (i.e., atrial fibrillation or paroxysmal supraventricular tachycardia) allowed
• Peripheral vascular disease = grade 2
• No serious or nonhealing active wound, ulcer, or bone fracture
• No history of seizures not well controlled with standard medical therapy
• No stroke or transient ischemic attack within the past 6 months
• No concurrent obstruction of the gastrointestinal or genitourinary tract

PRIOR CONCURRENT THERAPY:

• At least 4 weeks since prior radiotherapy to the pelvis
• Prior chemotherapy allowed
• No prior radiotherapy, hepatic thermal ablation, or resection (other than biopsy) to the liver
• No prior floxuridine
• No prior hepatic arterial infusion
• No concurrent chronic aspirin (> 325 mg/day) or nonsteroidal anti-inflammatory medications known to inhibit platelet function
• No other concurrent investigational agents

Related Conditions & MeSH terms

• Colorectal Cancer
• Colorectal Neoplasms
• Metastatic Cancer

Intervention

Drug:
• dexamethasone
Given by hepatic arterial infusion
• floxuridine
Given by hepatic arterial infusion
• fluorouracil
Given IV
• irinotecan hydrochloride
Given IV
• leucovorin calcium
Given IV
• oxaliplatin
Given IV

Locations

Country	Name	City	State
United States	Memorial Sloan Kettering Cancer Center	Basking Ridge	New Jersey
United States	Memorial Sloan Kettering Cancer Center @ Suffolk	Commack	New York
United States	Memorial Sloan Kettering Cancer Center	New York	New York
United States	Memorial Sloan Kettering at Mercy Medical Center	Rockville Centre	New York
United States	Memorial Sloan Kettering Cancer Center@Phelps Memorial Hospital	Sleepy Hollow	New York

Sponsors (2)

Lead Sponsor	Collaborator
Memorial Sloan Kettering Cancer Center	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Resectability rate		2 years
Secondary	Antitumor activity		2 years
Secondary	Response rate		2 years
Secondary	Median time to progression		2 years
Secondary	Survival		2 years

External Links

•   Memorial Sloan Kettering Cancer Center