Colorectal Cancer Clinical Trial
Official title:
Phase I/II Study of Xeloda and Gleevec in Patients With Advanced Solid Tumors
This study is for people with solid tumors cancer for which the standard chemotherapy drugs
have not worked. The purpose of this research is to evaluate the side effects of Xeloda
(also called capecitabine) in combination with a new anticancer agent called Gleevec (also
called imatinib mesylate). Xeloda is an anticancer drug, and can be taken by mouth. The
active ingredient is a well-studied cancer drug called 5-FU. Xeloda is approved by the FDA
for the treatment of colon cancer. Gleevec is approved in the US for the treatment of
patients with a leukemia called CML (increase of white blood cells) after failure of
standard therapy. It is also approved by the FDA for patients with Gastrointestinal Stromal
Tumors (a rare tumor in the digestive tract).
This study will test how much Gleevec we can safely give with Xeloda. Xeloda will be given
at the recommended dose for colorectal cancer and Gleevec will be given in increasing
amounts.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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