Colorectal Cancer Clinical Trial
Official title:
Familial Factors in the Development of Colon Cancer
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the
development of some types of cancer.
PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer
or adenomatous polyps.
OBJECTIVES:
- Identify human colon neoplasia susceptibility genes in patients with colon cancer or
adenomatous polyps.
- Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of
the colon with colon neoplasia in these patients.
- Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT
genes in these patients.
- Identify a novel gene that governs increased susceptibility to colon adenoma and cancer
in the genome of these patients.
;
Observational Model: Case-Only, Time Perspective: Prospective
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