Colorectal Cancer Clinical Trial
Official title:
Prospective Comparison of Air Contrast Barium Enema (ACBE), Computed Tomographic Colonography (Virtual Colonoscopy) and Colonoscopy for Evaluation of the Colon in Patients With Fecal Occult Blood
RATIONALE: Screening tests may help doctors detect cancer cells early and plan more
effective treatment for cancer. New diagnostic procedures such as computed tomographic
colonography may provide a less invasive method of identifying patients who have colon
cancer.
PURPOSE: Diagnostic and screening trial to compare the effectiveness of barium enema,
computed tomographic colonography, and colonoscopy in detecting of colon cancer.
OBJECTIVES:
- Compare the accuracy of air contrast barium enema, computed tomographic colonography
(virtual colonoscopy), and colonoscopy for the detection of colonic lesions in patients
with factors related to colon cancer.
- Compare the patient experience during each of these imaging tests.
OUTLINE: This is a multicenter study.
A repeat fecal occult blood test is performed. Patients then undergo an air contrast barium
enema (ACBE). At 7-10 days after ACBE, patients undergo a computed tomographic colonography
(virtual colonoscopy) followed by a colonoscopy on the same day.
A repeat ACBE may be performed if there is a discrepancy between the initial ACBE and
colonoscopy. If the repeat ACBE continues to show an abnormality, patients undergo a second
colonoscopy.
Within 24 hours of completion of each test, patients fill out a questionnaire about their
experience. At 5-7 days after completion of all tests, patients complete a final
questionnaire comparing all 3 tests.
PROJECTED ACCRUAL: A total of 2,133 patients will be accrued for this study within 4 years.
;
Primary Purpose: Diagnostic
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