Colonic Polyps Clinical Trial
Official title:
Detection of Colorectal Adenoma by Optical Enhancement Technology vs. High-Definition Colonoscopy: A Randomized Trial
Optical Enhancement Technology might be superior to the conventional HD-WL in detecting colorectal adenomas
Colorectal cancer is the third most common cancer in the world.Colonoscopy is the gold
standard screening test for colorectal cancer.There are also emerging data to support that
screening by colonoscopy reduces both the incidence and mortality of colorectal
cancer.However,Colonoscopy could still miss colorectal adenomas and even cancer.The miss
rate for colonic adenomas was reported to be ranging from 15 to 32% in tandem colonoscopy
studies.The reasons for the miss rate may be technical(insufficient during excessively fast
instrument withdrawal),but may also be the imaging method.Smaller lesions ,particularly flat
ones ,may be missed as a result of their subtle appearance and limited contrast in relation
to the surrounding mucosa.
Some image-enhanced modules were developed with an aim to improve colorectal polyp or
adenoma detection.The widely available modules is the narrow band imaging(NBI).However,most
studies failed to demonstrate any superiority of NBI system over white light colonoscopy in
detecting colonic polyps.NBI provides dimmer images of the colonic mucosa ,which may limit
its performance on polyp and adenoma detection.
Like NBI,OE technology is image-enhanced module,providing a more intense look at the
vascular pattern morphology.Besides,OE technology provides an much brighter image compared
to NBI.This may possibly increase polyp detection by enhancing visibility of the colonic
mucosa with brighter image.The current study aims to tested whether OE technology would
improve adenoma detection when compared with high-definition colonoscopy.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
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