Colonic Polyps Clinical Trial
Official title:
On-Site Endoscopic Prediction of Polyp Histology During Screening Colonoscopy
Polyps found during screening colonoscopy have to be removed or at least biopsied. Attempts to save costs include endoscopic assessment of polyps with regards to differential diagnoses between adenomas (which have to be removed) and hyperplastic polyps (could be left in place or removed and not examined histologically). Such a concept would only be feasible if endoscopy can make the differential diagnosis with high accuracy. Such high accuracy rates - between 80% and 95% - have been reported from reference centers with specific scientific interest. The investigators want to test whether these results a) can be reproduced in the private practice setting performing large-volume screening colonoscopies and b) whether latest generation endoscopes provide benefit in terms of better accuracy.
Patients undergoing screening colonoscopy will be randomized to the use of two different colonoscopes, namely the latest generation (Pentax iScan, Hi Line) versus the previous generation (Classic Line). On withdrawal, all polyps found will be diagnosed according to their pit pattern (classification scheme mit example images provided) and a differential diagnosis made during the live examination. Pit patterns I/II will be classified as hyperplastic polyps, patterns III-V as adenomas (in a subgroup IV and V will be classified as pre-/malignant). All polyps will be photographed from near distance to allow for later blinded review which will be done on patients with only one polyp (to avoid mix-up of polyps) by 3 examiners and 2 independent hospital experts. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05615857 -
Endocuff Enhanced Colonoscopy: Does it Improve Polyp Detection and Make Rectal Retroflexion Unnecessary
|
N/A | |
Not yet recruiting |
NCT02865382 -
Detection of Colorectal Adenoma by Optical Enhancement Technology vs. High-Definition Colonoscopy
|
N/A | |
Completed |
NCT02529007 -
Endo-cuff Assisted Vs. Standard Colonoscopy for Polyp Detection in Bowel Cancer Screening
|
N/A | |
Completed |
NCT02245854 -
Efficacy and Safety of a New Polypectomy Snare for Cold-polypectomy for Small Colorectal Polyps
|
N/A | |
Completed |
NCT01712048 -
Submucosal Injection EMR vs. Underwater EMR for Colorectal Polyps
|
N/A | |
Active, not recruiting |
NCT01368289 -
Australian Multicentre Colonic Endoscopic Mucosal Resection Study
|
||
Completed |
NCT02196649 -
Clip Placement Following Endoscopic Mucosal Resection - Randomised Trial
|
N/A | |
Not yet recruiting |
NCT00996619 -
Measuring the Spectrum of Tissues During Endoscopy
|
N/A | |
Completed |
NCT00997802 -
Japanese National Computed Tomographic (CT) Colonography Trial
|
N/A | |
Completed |
NCT00468455 -
Post-Op Quality of Life After Colorectal Surgery
|
N/A | |
Completed |
NCT00018551 -
Chemoprevention With Folic Acid
|
Phase 2 | |
Recruiting |
NCT02552017 -
Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities
|
N/A | |
Completed |
NCT01979458 -
Photometric Stereo Endoscopy (PSE) as a Tool for Imaging the Rectum and Colon
|
N/A | |
Unknown status |
NCT01101672 -
Trial for Single Port Versus Conventional Laparoscopic Colectomy
|
Phase 2/Phase 3 | |
Terminated |
NCT01458925 -
Feasibility of Check-Cap's P1 Capsule System Screening
|
N/A | |
Recruiting |
NCT05737017 -
The Efficacy and Safety of a Hybrid Hemostatic Device (ClearCoajet)
|
N/A | |
Recruiting |
NCT02760381 -
Acetic Acid for Optical Characterization of Colonic Polyps
|
N/A | |
Withdrawn |
NCT04253990 -
Efficacy and Safety of Precut-EMR for Resecting of Colonic Polyp
|
N/A | |
Completed |
NCT01901510 -
Panchromoendoscopy Using Oral Indigo Carmine Mixed With Polyethylene Glycol Prep
|
Phase 1 | |
Completed |
NCT01761279 -
High Definition Endoscopy With i-Scan for Small Colonic Polyp Evaluation: The HiScope Study
|
N/A |