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NCT05200052 Clinical Trial

Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking

Colchicine Clinical Trial

Official title:
Effect of Colchicine Use On Left Ventricle Systolic Function Using Speckle Tracking Echocardiography in Patients With Anterior S-T Segment Elevation Myocardial Infarction

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05200052
Other study ID # FMASUMD88/2020
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date February 1, 2022
Est. completion date August 1, 2022

Study information
Verified date August 2022
Source Ain Shams University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography longitudinal strain pattern

Description:

The study participants are patients presented with anterior myocardial infarction. They will be divided into 2 groups. The first group will receive colchicine loading dose of 1mg then 0.5 mg maintenance dose in addition to the standard anti ischemic treatment for 6 months. The other group will only receive the standard anti ischmic treatment. Speckle tracking echocardiography will be done to all patients to assess left ventricular longitudinal strain pattern.

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date August 1, 2022
Est. primary completion date August 1, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: ??Anterior S-T segment elevation myocardial infarction with time of presentation less than 12 hours. Exclusion Criteria: - Severe renal impairment. - Cardiac arrest. - Cardiogenic shock.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Colchicine 0.5 mg Oral Tablet
Colchicine loading dose 1 mg and maintenance dose 0.5 mg for 6 months in addition to standard anti ischemic treatment.

Locations
Country Name City State
Egypt Ain Shams University hospitals Cairo

Sponsors (1)
Lead Sponsor Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Average of global longitudinal strain pattern Assessment of left ventricular longitudinal strain by speckle tracking echocardiography after beforr and after colchicine 6 months
Secondary Number of mortality during study Death from any cause 6 months
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