Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients

Cohort Studies Clinical Trial

Official title: Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety

Status Completed

Clinical Trial Summary

This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.

Clinical Trial Description

Studies have suggested volatile anaesthetics may alleviate depression and anxiety in patients. However, there is a paucity of research in this area. The investigatorswanted to determine the association between volatile anaesthetics and depression/anxiety in elderly patients within 7 days after surgery.

This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 18 tertiary hospitals across 10 provinces in China. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied. ;

Related Conditions & MeSH terms

• Cohort Studies
• Depression

• NCT number: NCT06307717
• Study type: Observational [Patient Registry]
• Source: Chinese PLA General Hospital
• Status: Completed
• Start date: April 1, 2020
• Completion date: April 30, 2022