COMO: Cognition Study With HIV+ Patients (CTNPT 015) — COMO  

Cognitive Symptoms Clinical Trial

Official title: CTNPT 015 - Pilot Project to Implement a Step-wise Investigation That Includes Cerebrospinal (CSF) Analysis as a Standard of Care for HIV+ Individuals With Cognitive Symptoms

Status Terminated

Clinical Trial Summary

The purpose of this study is to contribute evidence towards the potential to improve cognition in HIV+ individuals experiencing cognitive decline through personalized change in antiretroviral (ARV) medication. To that end, following a comprehensive evaluation to identify confounding clinical conditions, study participants will undergo a lumbar puncture to: (i) measure viral load (at 2 copies/ml); (ii) identify Cerebrospinal Fluid (CSF) genotype and tropism; and (iii) measure concentration of antiretroviral agents. When indicated from the CSF analysis, a personalized change in ARV will be implemented. Cognition will be measured in all at study entry and 6 months later.

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Acquired Immunodeficiency Syndrome
• Cognitive Symptoms
• HIV - Human Immunodeficiency Virus
• HIV Infections
• Immunologic Deficiency Syndromes
• Neurobehavioral Manifestations

• NCT number: NCT02144688
• Study type: Interventional
• Source: McGill University Health Center
• Status: Terminated
• Phase: Phase 0
• Start date: June 2011
• Completion date: March 2016