Cognitive Impairment Clinical Trial
Official title:
Cognitive Training in Heart Failure Study (CogTrain-HF)
The daily routine in clinical settings often showed cognitive impairments in patients with congestive heart failure, particularly in terms of executive functions, episodic memory, perceptual speed and attention. It is assumed that cognitive impairments in patients with congestive heart failure may lead to deficits in medication-adherence and self-care abilities, resulting in increased healthcare costs. Recent studies reported performance improvements after cognitive training that transferred to new, untrained tasks and abilities in healthy subjects across a wide range of ages. This study investigates the effects of cognitive training in patients with congestive heart failure.
Cognitive functions of patients with congestive heart failure (NYHA II-III) before (pretest)
and after (posttest) cognitive-training intervention are investigated. Changes in cognitive
functions are compared to changes in two control groups: 1) age and gender matched active
control group 2) age and gender matched passive waiting list control group.
The neuropsychological test battery applied at pretest and posttest includes measures of
episodic memory, working memory, short-term memory, executive functions, perceptual speed and
intelligence. In addition, the investigators apply standardized questionnaires of
self-assessed quality of life, cognitive functioning in daily life, selfcare, and
psychological well-being (depression, anxiety and personality). Relevant physiological data
such as ejection fraction, heartrate, N-terminal pro brain natriuretic peptide (NT-pro-BNP)
as well as drug blood level are recorded.
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