Resistance Training on Growth Factors

Cognitive Function Clinical Trial

Official title:

Acute Effect of Resistance Training With Different Intensity on Circulating Levels of Neurotrophic Growth Factors and Homocysteine in Young Adults

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06114550
• Other study ID #: zuochongwen
• Status: Not yet recruiting
• Phase: N/A
• Start date: February 27, 2024
• Est. completion date: April 7, 2024

Study information

• Verified date: January 2024
• Source: Air Force Military Medical University, China
• Contact: Chongwen Zuo, Doctoral
• Phone: +86 18810716505
• Email: zuochongwen[@]cupes.edu.cn
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:

1. Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.

2. whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.

Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).

Researchers will compare the training effects of two different training on these growth factors.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 12
• Est. completion date: April 7, 2024
• Est. primary completion date: March 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• age between 18 to 30 years

• no experiencing musculoskeletal disorders or sports injuries

• had not participated any regular aerobic endurance or resistance training with in the previous half years

• no smoking habit or intake alcohol and other medication (e.g., steroid hormone)

• good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)

Exclusion Criteria:

• experiencing musculoskeletal disorders or sports injuries in recent 1 month

• had regular resistance training exercise

• intake any supplementary(drug and hormone)

Related Conditions & MeSH terms

• Cognitive Function

Intervention

Other:
• High intensity resistance training
The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.
• Low intensity resistance training
For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Air Force Military Medical University, China

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rata of perceived exertion	The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.	"0 minutes" "60 minutes" "90 minutes"
Primary	Blood lactate	serum blood lactate	"0 minutes" "60 minutes" "90 minutes"
Primary	BDNF	regulators of neurogenesis	"0 minutes" "60 minutes" "90 minutes"
Primary	IGF-1	regulators of neurogenesis	"0 minutes" "60 minutes" "90 minutes"
Primary	VEGF	regulators of neurogenesis	"0 minutes" "60 minutes" "90 minutes"
Primary	Irisin	regulators of neurogenesis	"0 minutes" "60 minutes" "90 minutes"
Primary	Hcy	homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction	"0 minutes" "60 minutes" "90 minutes"
Secondary	Reactive time	Reaction time is the time it takes for the body to go from receiving a stimulus to responding to an action	"0 minutes" "60 minutes" "90 minutes"
Secondary	Accuracy rate	Accuracy refers to the correct degree of expression or description of a thing, which is used to reflect the correct answer to the thing	"0 minutes" "60 minutes" "90 minutes"