The Effect of Aronia Melanocarpa Extract on Cognitive Function

Cognitive Function Clinical Trial

Official title:

The Effect of Short-term Aronia Melanocarpa Extract Supplementation on Cognitive Function in Healthy Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03793777
• Other study ID #: Brainport_002
• Status: Completed
• Phase: N/A
• Start date: October 9, 2020
• Est. completion date: April 29, 2021

Study information

• Verified date: September 2020
• Source: Maastricht University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance . Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance.

Description:

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance. Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance. The product in this study is aronia melanocarpa which contains polyphenols. A limited number of clinical studies have already been carried out to see the effect of similar products on cognitive functioning. However, these studies have often been done in older study populations or over a longer period of time. In this study, in healthy adolescents (ages between the 18-35 and with a BMI between 18.5 and 30), the investigators want to test the short term (7 days) effect of aronia melanocarpa extract on cognitive functioning. The investigators will also test the effect of supplementation on the particpant's mood, vascular function, blood biomarkers, retinal vasculature, and subjective cognition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: April 29, 2021
• Est. primary completion date: April 29, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy young adults: ages between 18 and 35

• BM between 18.5-30 kg/m2

Exclusion Criteria:

• Current use of (antioxidant) dietary supplements and not willing to quit for the duration of the study duration

• Pre-existing or history of neurological illness

• High blood pressure (>140 systolic and/or >90 diastolic mmHg)

• Use of medication that might have influence on endpoints (e.g. antidepressant)

• Known pregnancy or lactation

• Food allergy to the study product

• Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study, to be decided by the principle investigator, in the 180 days prior to the study

• Abuse of products (> 20 alcoholic consumptions per week and drug usage)

• Participation in a scientific intervention study which may interfere with this study in the 180 days prior to this study

Related Conditions & MeSH terms

• Cognitive Function

Intervention

Dietary Supplement:
• Aronia
daily supplementation
• Placebo
daily supplementation

Locations

Country	Name	City	State
Netherlands	Maastricht University	Maastricht	Limburg

Sponsors (2)

Lead Sponsor	Collaborator
Maastricht University Medical Center	BioActor B.V.

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cognitive function	CANTAB	After 7 days of supplementation
Secondary	Mood	VAMS	After 7 days of supplementation
Secondary	Biomarkers in blood and saliva	BDNF & cortisol	After 7 days of supplementation
Secondary	Vascular function	SBP & DBP, PWA & PWV	After 7 days of supplementation
Secondary	Microvasculature	Fundus photography	After 7 days of supplementation
Secondary	Subjective cognition	Cognitive Failures Questionnaire	After 7 days of supplementation