High-intensity Interval Exercise and Chocolate Milk on Blood Glucose and Cognition

Cognitive Function Clinical Trial

Official title:

The Effects of High-intensity Interval Exercise and Chocolate Milk on Glycemic Control and Cognitive Function in Children.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03305107
• Other study ID #: REB2017- 088
• Status: Completed
• Phase: N/A
• Start date: July 8, 2017
• Est. completion date: May 31, 2018

Study information

• Verified date: August 2018
• Source: Ryerson University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the separate and combined effects of high-intensity interval exercise and chocolate milk on glycemic response, cognitive function, subjective appetite, and salivary cortisol among children aged 9-13 year old children.

Description:

Twenty children 9-13 years of age will be recruited for this study. On four separate mornings, after a 10 hour overnight fast, each child will consume a standardized breakfast (including orange juice, a strawberry breakfast bar and a pear fruit cup) at home. Using a 2x2 factorial design, 2 hours after breakfast consumption, each participant will arrive in the lab (T=-20 min) and participate in high-intensity interval exercise or sit quietly for 20 min, followed by a treatment drink of chocolate milk or water (control) consumption in 10 min. During high-intensity interval exercise treatment, children will exercise on a cycle ergometer with a 3-min warm-up, 7 repeated bouts of 60-sec exercise at 90% of peak power output and 60-second recovery, and a 3-min cool down. Blood glucose will be measured via finger-prick at baseline (-20 min), 10, 30, 60, and 90 min. Cognitive functions will be measured using a battery of cognitive tests which assess verbal declarative memory, working memory, and executive functioning, and will be measured at baseline, 10. 30. 60, and 90 min. Subjective appetite and emotions will be measured using a 100-mm visual analogue scale (VAS) at baseline, 10, 30, 60, and 90 min. Salivary cortisol will be assessed from saliva samples collected using the passive drool method, and will be collected at baseline, 10 and 30 min.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: May 31, 2018
• Est. primary completion date: December 31, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 9 Years to 13 Years

Eligibility

Inclusion Criteria:

• be between 9 and 13 years of age

• be healthy, and have been born at term

• not be taking any medications

• not have allergies to dairy or gluten.

Exclusion Criteria:

• Food sensitivities, allergies, or dietary restrictions

• Health, learning, emotional, or behavioural problems

• Receiving any medications

• Non-habitual breakfast eater (<5 days/week)

Related Conditions & MeSH terms

• Cognitive Function
• Glycemic Response

Intervention

Other:
• Exercise and Chocolate Milk
High intensity interval exercise Chocolate Milk
• Exercise and Water
High intensity interval exercise Water
• Sitting and Chocolate Milk
Sitting Chocolate Milk
• Sitting and Water
Sitting Water

Locations

Country	Name	City	State
Canada	School of Nutrition, Ryerson University	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Ryerson University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline Glycemic Response	Blood samples will be collected via finger-prick method to assess glycemic response (blood glucose, mmol/L)	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Primary	Change from baseline verbal declarative memory	Cognitive function test of verbal declarative memory	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Primary	Change from baseline working memory	The n-back test consists of 2 levels, 1-back and 2-back, where letters are presented on the screen one at a time. During the 1-back level, participants need to determine if the presented letter is the same as the one letter presented 1 before it or not (by selected 'match' or 'no match' on the side of the screen) and during 2-back need to do determine if it is the same letter as the one presented 2 letters prior.	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Primary	Change from baseline executive functioning	The Stroop test consists of one word appearing on the screen written in either blue, red, yellow or green. There are 24 congruent trials where the presented word is the name of the colour it is written it (i.e. 'red' appearing in the colour red), 24 incongruent trials where the word written is a colour word different from the one it is written in (i.e. 'red' appearing in the colour green), and 10 neutral trials where non-colour words appear (i.e. 'tape' appearing in yellow). The participant is asked to tap the corresponding colour that the word is written in as quickly as possible.	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline salivary cortisol response	Saliva samples will be collected via passive drool method to assess salivary cortisol response (ug/dL)	baseline (-20 min), and 10 and 30 min post-drink consumption
Secondary	Change form baseline Subjective Appetite	100-mm Visual Analogue Scales (VAS) will be used to assess appetite	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline aggression	100-mm Visual Analogue Scales (VAS) will be used to assess aggression	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline anger	100-mm Visual Analogue Scales (VAS) will be used to assess anger	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline excitement	100-mm Visual Analogue Scales (VAS) will be used to assess excitement	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline disappointment	100-mm Visual Analogue Scales (VAS) will be used to assess disappointment	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline happiness	100-mm Visual Analogue Scales (VAS) will be used to assess happiness	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline upset	100-mm Visual Analogue Scales (VAS) will be used to assess upset	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change form baseline frustration	100-mm Visual Analogue Scales (VAS) will be used to assess frustration	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline alertness	100-mm Visual Analogue Scales (VAS) will be used to assess alertness	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline sadness	100-mm Visual Analogue Scales (VAS) will be used to assess sadness	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline tension	100-mm Visual Analogue Scales (VAS) will be used to assess tension	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline exhaustion	100-mm Visual Analogue Scales (VAS) will be used to assess exhaustion	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Secondary	Change from baseline sleepiness	100-mm Visual Analogue Scales (VAS) will be used to assess sleepiness	baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption