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NCT00494689 Clinical Trial

Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia

Cognitive Function Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00494689
Other study ID # 02
Secondary ID
Status Recruiting
Phase N/A
First received June 28, 2007
Last updated June 28, 2007
Start date January 2002
Est. completion date June 2007

Study information
Verified date June 2007
Source Devathasan Neurology Practice Pte Ltd
Contact Devathasan Gobinathan, FRCP,MD
Phone 65-67330311
Email devathasan@msn.com
Is FDA regulated No
Health authority Singapore: Health Science AuthorityCanada: University of British Columbia; Dept of Science.
Study type Observational

Clinical Trial Summary

The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia and dilated ventricles who improve when treated with transcranial monitoring or low ultrasound wave intensity (milliwatts) and with rapid magnetic stimulation which is also a diagnostic tool routinely used by many neurophysiologists. Before, these patients will progress and may need a brain shunt called Ventriculo-peritoneal shunt. He and collaborators now would like to do a double study as this appears to be a cheap and effective alternative treatment and help patients to walk again.

Description:

The transcranial monitoring intensity would be equivalent to the well known CLOTBUST study (<300mw/sq cm)for one hour, using two probes.

All will be treated as an outpatient and there is no form of infusion or interventional treatment.

The rapid magnetic stimulation is at about 50a/us, 15Hz, 1000 pulses with 10 sec pause for ten days along the skull vault. Informed consent will be obtained. 30 patients will be recruited and sham treatment would be just applying probe without power for transcranial and for magnetic stimulation coil will be angled away. Data will be compiled by a separate blinded investigator and so with the statistics. VP shunt failure patients, which is common, will be included. Barthel's daily living index and standard cognitive tests will be used to assess results.

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date June 2007
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- cerebral ischemia with our without hydrocephalus and gait apraxia

Exclusion Criteria:

- all other conditions which contribute to walking difficulty e.g. bad knees; or spondylosis; parkinson's or paralytic strokes

Study Design

Observational Model: Case Control, Time Perspective: Longitudinal

Related Conditions & MeSH terms

Locations
Country Name City State
Singapore Devathasan Neurology Practice Singapore
Singapore Devathasan Neurology Practice #11-16 MEMC Singapore

Sponsors (1)
Lead Sponsor Collaborator
Devathasan Neurology Practice Pte Ltd

Country where clinical trial is conducted

Singapore, 

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