Cognitive Dysfunction Clinical Trial
Official title:
Impact of the Digital Multi-domain Cognitive Intervention in High-risk Populations for Dementia
Dementia is a chronic, progressive neurodegenerative disease characterized by acquired cognitive impairment as its core manifestation. The most common type of dementia is Alzheimer's Disease (AD), also known as "Senile Dementia," accounting for 60-80% of all dementia cases. Currently, there are approximately 10 million AD patients in China, with the number showing an increasing trend year by year, imposing a heavy economic and caregiving burden on families and society. Studies have shown that AD has a clinically silent period of 15 to 20 years (SCD\MCI), where the risk of developing dementia is ten times higher than that of healthy elderly individuals. Nearly 50% of MCI patients progress to dementia within 5 years, and about 14.1% of SCD patients develop dementia within the same timeframe. Early detection, diagnosis, and intervention are currently the most effective strategies for preventing and treating AD. Therefore, this study aims to verify the intervention effect of integrated cognitive intervention in high-risk populations for senile dementia (SCD, MCI) based on the cognitive rehabilitation model through randomized controlled trials, and to analyze attrition rates, participation rates, etc., which have good research and application value.
Based on the cognitive rehabilitation model, this study aims to develop a digital multimodal cognitive intervention program, and conduct feasibility studies and randomized controlled trials. The intervention includes health knowledge education, exercise intervention, art intervention, and cognitive training, etc. The feasibility, effectiveness, and safety of this intervention approach will be evaluated. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05273125 -
MOBility Disorders Assessment in Patients With Mild COGnitive Disorders
|
||
| Active, not recruiting |
NCT04049695 -
Improving Cognition After Cancer
|
N/A | |
| Completed |
NCT05912374 -
Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs
|
N/A | |
| Recruiting |
NCT03977350 -
Association Between qEEG Measure and Post-Operative Cognitive Dysfunction (POCD) and Postoperative Delirium (POD)
|
||
| Not yet recruiting |
NCT06027632 -
Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in Patients Treated for Localized Breast Cancer
|
N/A | |
| Terminated |
NCT00754013 -
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
|
Phase 3 | |
| Completed |
NCT00719628 -
Depth of Anaesthesia and Cognitive Dysfunction
|
N/A | |
| Terminated |
NCT00754052 -
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17
|
Phase 3 | |
| Recruiting |
NCT05014399 -
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
|
||
| Completed |
NCT04966455 -
Effect of Raisins on Cognitive Function in Healthy Older Adults
|
Phase 3 | |
| Recruiting |
NCT05372159 -
Vanderbilt Memory and Aging Project
|
||
| Completed |
NCT03243279 -
BRS and Outcomes in Cardiothoracic Surgery
|
||
| Completed |
NCT04093882 -
The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease
|
||
| Recruiting |
NCT05732285 -
A Pilot Randomized Controlled Trial: CoINTEGRATE
|
N/A | |
| Completed |
NCT06059768 -
Urdu Translation and Psychometric Analysis of Lawton IADLS.
|
||
| Completed |
NCT04624529 -
Validity and Reliability of a Self-evaluation Tool for Cognitive Deficits in the Acute Stage After Stroke
|
||
| Completed |
NCT04562662 -
Evaluation of mediVR-KAGURA Guided Therapy
|
N/A | |
| Not yet recruiting |
NCT04079075 -
Multiple Interventions to Prevent Cognitive Decline
|
N/A | |
| Active, not recruiting |
NCT04638101 -
Building the Path to Resilience in Preterm Infants: Mindfulness-based Intervention
|
N/A | |
| Active, not recruiting |
NCT04556305 -
Lifestyle Physical Activity and Cognitive Training Interventions
|
N/A |