Cognition Clinical Trial
Official title:
The Acute Effects of a High Versus Low Dose of a Ketone Monoester Supplement on Cerebral Blood Flow and Cognition
Ketone bodies are produced by the liver during periods of food scarcity or severe carbohydrate restriction. Blood ketones are an alternative fuel source used by the brain, heart, and skeletal muscle during periods of fasting. Further, ketones bodies act as a signalling molecule that have pleiotropic effects that upregulate cellular stress-resistance pathways throughout the body. Oral supplements containing exogenous ketones have recently become available and represent a novel tool for increasing plasma ketone bodies without the need for dietary restriction. Early evidence suggests that oral ketone supplements may enhance cerebral blood flow and improve cognition. However, the dose-dependent effects of a single ketone supplement on cerebral blood flow and cognition in young adults is currently unknown. The purpose of this study is to characterize the effects of ingesting a high versus low dose of an oral ketone monoester on cerebral blood flow, circulating blood markers, and cognition in young adults. As an exploratory aim, this study will investigate how oxygen uptake kinetics during submaximal exercise are impacted 2 hours after ingestion of a ketone supplement. Recent findings indicate that ketone supplementation may impair exercise performance due to the physiological stress (i.e., pH disturbances) imposed by an acute ketone dose. Delaying exercise onset by 2 hours after ingestion of a ketone supplement may enhance oxygen kinetics in a dose-dependent manner.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT04540523 -
Home-Based Exergaming Intervention
|
N/A | |
| Suspended |
NCT01212029 -
Testing and Calibration of Non-Invasive Optical Imaging Technology for Functional Brain Imaging
|
N/A | |
| Enrolling by invitation |
NCT05273970 -
Electrochemical and Electrophysiological Study
|
N/A | |
| Recruiting |
NCT05227352 -
Bio-Experiential Spaces for Mental Health in Healthworkers
|
N/A | |
| Completed |
NCT02671149 -
The Effect of Small Changes in Hydration on Cognition
|
N/A | |
| Completed |
NCT01333306 -
Enhancing Cognitive Training Using tDCS
|
Phase 1 | |
| Recruiting |
NCT05542199 -
Nutrition for Brain and Body Health (BB-Health) Feasibility Trial
|
N/A | |
| Recruiting |
NCT06331286 -
The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity
|
N/A | |
| Recruiting |
NCT06254638 -
Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)
|
N/A | |
| Completed |
NCT05998096 -
A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, Reaction Time, and Other Perceptual Indicators
|
N/A | |
| Withdrawn |
NCT03224559 -
Applying Neuromodulation to Accelerate Training Effects
|
||
| Completed |
NCT03129048 -
Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults
|
N/A | |
| Recruiting |
NCT05394363 -
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
|
||
| Suspended |
NCT05107947 -
Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm
|
N/A | |
| Recruiting |
NCT05372172 -
Tennessee Alzheimer's Project
|
||
| Recruiting |
NCT05132517 -
Magnesium and Cognition After Stroke
|
||
| Recruiting |
NCT05992571 -
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
|
N/A | |
| Recruiting |
NCT06097182 -
Postbiotic Intervention for Acute Stress Management
|
N/A | |
| Completed |
NCT01223404 -
Nicotinic Modulation of the Default Network
|
N/A | |
| Completed |
NCT00687102 -
Cognition in the Study of Tamoxifen and Raloxifene
|
Phase 3 |