Effects of Breaking Sitting on Human Behaviour and Metabolic Health

Cognition Clinical Trial

Official title:

Effects of Breaking Prolonged Sitting on 24-h Human Behaviours, Self-feelings, Metabolic Health and Cognition in Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05911490
• Other study ID #: 2-108-05-151
• Status: Completed
• Phase: N/A
• Start date: December 20, 2019
• Est. completion date: September 29, 2020

Study information

• Verified date: June 2023
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study primarily aimed to investigate effects of breaking up prolonged sitting with intermittent brisk walking in healthy young individuals on (1) post-trial human behaviours including energy intake and physical activity under free-living conditions and (2) cognitive performance in a simulated workplace environment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: September 29, 2020
• Est. primary completion date: September 29, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• Without current and any history of brain injury, neurological disorder, cardiometabolic related diseases, diabetes or cancers.
• Weight stable (not self-reported weight change ± 3 kg at least 3 months)
• Body mass index (BMI) ranging between 18.5 to 27 kg/m2
• Can walk safely on a treadmill

Exclusion Criteria:

• Smokers, post-menopausal female, and volunteers who used any medications that could influence metabolic and inflammatory responses.

Related Conditions & MeSH terms

• Cognition
• Energy Balance
• Metabolic Health
• Physical Activity Level

Intervention

Behavioral:
• Prolonged sitting
In the laboratory, after consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.
• Breaking prolonged sitting
In the laboratory, after consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

Locations

Country	Name	City	State
Taiwan	National Taiwan Normal University	Taipei

Sponsors (2)

Lead Sponsor	Collaborator
National Taiwan Normal University	Division of Endocrinology and Metabolism, Tri-Service General Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Physical activity level	Changes in physical activity level (steps) in the free-living conditions	480 minutes
Primary	Energy intake	Changes in energy intake (kcal) in the free-living conditions	480 minutes
Primary	Cognitive performance	Changes in cognitive performance (% changes in accuracy) including Task Switching and Flanker tasks	320 minutes
Primary	Cognitive function	Changes in cognitive performance (% changes in reaction time) Task Switching and Flanker tasks	320 minutes
Secondary	Postprandial glucose concentrations	Changes in postprandial finger pricking glucose concentrations	320 minutes
Secondary	Blood pressure	Changes in systolic blood pressure and diastolic blood pressure	320 minutes
Secondary	Visual analogue scale (VAS)	Changes in self-perceived sensations including appetite, energy and mood (score from 0-100)	320 minutes
Secondary	Continuous glucose monitoring	Changes in different depots of adipose tissue interstitial glucose concentrations	320 minutes