Effect of Normal Aging on Language Processing

Cognition Clinical Trial

— SEMVIE  

Official title:

Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches.

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02189460
• Other study ID #: 2014-AZ00569-38
• Status: Terminated
• Start date: July 2014
• Est. completion date: July 2018

Study information

• Verified date: October 2018
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 33
• Est. completion date: July 2018
• Est. primary completion date: July 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years and older

Eligibility

Inclusion Criteria:

• Age of 30 years and above

• Right handed

• French native speakers

• Affiliation to French social security (Sécurité Sociale)

• Medical interview

• Consent form signed

Exclusion Criteria:

• Cerebral or respiratory pathologies

• Any MRI contrindication

Related Conditions & MeSH terms

• Cognition

Locations

Country	Name	City	State
France	IRMaGe facility	Grenoble

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood Oxygen Level Dependent functional MRI	We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects.; We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.	There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.
Primary	Anatomical MRI	We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects.; We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.	There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.