Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults

Cognition Clinical Trial

Official title:

Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults Aged 15-21 Years

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02075944
• Other study ID #: S-20130171
• Status: Completed
• Phase: N/A
• First received: February 27, 2014
• Last updated: June 25, 2014
• Start date: February 2014
• Est. completion date: June 2014

Study information

• Verified date: June 2014
• Source: University of Southern Denmark
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: Ethics CommitteeDenmark: Danish Dataprotection Agency
• Study type: Interventional

Clinical Trial Summary

The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Subjects randomized to the exercise groups will complete 30 minutes of aerobic exercise 3 times a week for 9 weeks incorporating low (group I) or high (group II) intensity aerobic exercise. The exercise will be conducted as running or indoor cycling (supervised). At baseline and 9-weeks follow-up all subjects will complete two cognitive tests (measures of concentration and sustained attention), a maximal cycling test (direct measures of VO2max), an intelligence quotient test, anthropometric measures, fasting blood samples and blood samples immediately following the cycling test. The blood samples will be analyzed for growth factors including BDNF and metabolic factors.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 130
• Est. completion date: June 2014
• Est. primary completion date: June 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 15 Years to 21 Years

Eligibility

Inclusion Criteria:

• age 15-21

Exclusion Criteria:

• injury preventing one from being physically active

Study Design

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind (Investigator), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Cognition
• Physical Conditioning, Human

Intervention

Behavioral:
• High intensity aerobic exercise

• Low intensity aerobic exercise

Locations

Country	Name	City	State
Denmark	University of Southern Denmark	Odense

Sponsors (1)

Lead Sponsor	Collaborator
University of Southern Denmark

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The Flanker Task		9 weeks	No
Primary	The AX-Continuous Performance test		9 weeks	No
Primary	Brain-derived neurotrophic factor		9 weeks	No
Secondary	Intelligence quotient		9 weeks	No