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Clinical Trial Summary

A significant number of patients experience postoperative cognitive changes following total joint arthroplasty. Among other causes, the mental status change may be the result of fat and bone marrow debris embolization. We hypothesized that the use of computer assisted total knee arthroplasty, which does not utilize intramedullary alignment rods, would produce less fat and bone marrow debris embolization and, hence, fewer mental status changes.


Clinical Trial Description

Inclusion criteria

- Primary, cemented knee arthroplasty

- Unilateral or bilateral TKA

Exclusion criteria

- Patient is unable to speak English

- Unable to read and write

- Patient with history of psychiatric disorders (Depression, Schizophrenia, anxiety, bipolar dis.)

- Patients with history of IV drug abuse

- Previous history of dementia

- Patients on mental status changing medications ;


Study Design

Observational Model: Case Control, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT00830986
Study type Observational
Source Rothman Institute Orthopaedics
Contact
Status Completed
Phase N/A
Start date July 2005
Completion date March 2006

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