Buprenorphine Naltrexone-P1 A-Cocaine

Status Completed

Clinical Trial Summary

The purpose of this study is to determine if the opioid agonist effects of doses of 4/1 mg, 8/2 mg, and 16/4 mg of buprenorphine/naloxone can be completely blocked by 50 mg of oral naltrexone. This study will provide data to support the design of a similar study of the depot formulation of naltrexone and ultimately to study this combination for the treatment of cocaine dependence.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Cocaine-related Disorders

Clinical Trial Details

NCT number	NCT00733720
Study type	Interventional
Source	National Institute on Drug Abuse (NIDA)
Contact
Status	Completed
Phase	Phase 1
Start date	August 2008
Completion date	January 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01526538` - Improving Learning-based Treatment of Cocaine Dependence With Medication	Phase 2
Completed	`NCT00877435` - Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial	N/A
Completed	`NCT00430690` - Acoustic Startle Reduction In Cocaine Dependence
Completed	`NCT00217997` - Impulsivity, Brain Function, and Substance Abuse Treatment in Cocaine Dependent Individuals	N/A
Active, not recruiting	`NCT00094315` - Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1	Phase 1
Terminated	`NCT00142883` - The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3	N/A
Completed	`NCT00218348` - Treatment of Cocaine Dependence: Comparison of Three Doses of Dextro-Amphetamine Sulfate and Placebo	Phase 2
Completed	`NCT00142844` - Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1	Phase 2
Completed	`NCT00158132` - Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2	Phase 2
Completed	`NCT00000294` - Effects of Carvedilol on Cocaine Use in Humans - 11	Phase 2
Completed	`NCT00015054` - Methylphendidate Treatment of Cocaine Dependent Patients With Attention Deficit Hyperactivity Disorder - 3	Phase 2
Completed	`NCT00000308` - Dextroamphetamine-Cocaine Behavioral Intervention - 5	Phase 2
Completed	`NCT00000188` - Selegiline in Treatment of Cocaine Dependence - 2	Phase 2
Completed	`NCT00000278` - Disulfiram for Cocaine-Alcohol Abuse - 3	Phase 2
Terminated	`NCT00000276` - Dopamine Reuptake Inhibitors of Cocaine Abuse - 1	Phase 1
Completed	`NCT00000281` - Pharmacotherapy for Schizophrenic Drug Users - 6	Phase 2
Completed	`NCT00000280` - Glutaminergic Agents for Cocaine Abuse - 5	Phase 1
Completed	`NCT00000306` - Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3	Phase 2
Completed	`NCT00000314` - M-CPP and Fenfluramine in Cocaine Addicts - 3	Phase 2
Completed	`NCT00000277` - Mazindol for Cocaine Abuse - 2	Phase 2