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Cocaine-Metyrapone Interaction Study - 1

Cocaine-Related Disorders Clinical Trial

Official title:
Cocaine-Metyrapone Interaction Study

Clinical Trial Summary

The purpose of this study is to examine the safety of two consecutive days of metyrapone (MRP) in subjects who may use cocaine concurrently.

Clinical Trial Description

To evaluate the safety of metyrapone (MRP) for using in an outpatient study in which participants would be given 2 750 mg doses of MRP per week. Secondary study goals are to evaluate the possible efficacy of MRP as a treatment for cocaine dependence and to compare 3 factors hypothesized to induce cocaine craving: cocaine cues, stress, and cocaine itself. This study will utilize a Double Blind, placebo-controlled crossover design with 3 factors: 1) medication 2) relapse trigger and 3) infusion for an 11 day in-patient treatment. ;

Study Design

Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00033098
Study type Interventional
Source National Institute on Drug Abuse (NIDA)
Contact
Status Active, not recruiting
Phase Phase 1
Start date November 2001
Completion date May 2002
View Details
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