Selegiline in Outpatient Treatment for Cocaine Dependence - 1

Cocaine-Related Disorders Clinical Trial

Official title:

Safety and Efficacy of Selegiline in Outpatient Treatment for Cocaine

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00000336
• Other study ID #: NIDA-3-0010-1
• Secondary ID: Y01-3-0010-1
• Status: Completed
• Phase: Phase 2
• First received: September 20, 1999
• Last updated: January 13, 2017
• Start date: January 1995
• Est. completion date: March 1996

Study information

• Verified date: January 1996
• Source: National Institute on Drug Abuse (NIDA)
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy and clinical safety of selegiline in the treatment of cocaine dependence and to assess neurotoxicity (Magnetic Resonance Imaging, MRI) post-hoc as a possible variable for future stratification in clinical trials.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: March 1996
• Est. primary completion date: February 1996
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years to 50 Years

Eligibility

Inclusion Criteria:

M/F ages 21-50. Meets DSM-IV criteria for cocaine. Agreeable to conditions of study and signed informed consent.

Exclusion Criteria:

Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical conditions that deem participation to be unsafe.

Related Conditions & MeSH terms

• Cocaine-Related Disorders

Intervention

Drug:
• Selegiline

Locations

Country	Name	City	State
United States	Friends Research Institute	Los Angeles	California

Sponsors (1)

Lead Sponsor	Collaborator
National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Urine toxicology for cocaine
Primary	Self reports of cocaine and other drug use and craving
Primary	Evidence of change in neurotoxicity based on choreoathetoid movement assessments