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Cocaine-Related Disorders clinical trials

View clinical trials related to Cocaine-Related Disorders.

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NCT ID: NCT04907357 Active, not recruiting - Cocaine Dependence Clinical Trials

rTMS for Stimulant Use Disorders

CTN-0108
Start date: February 4, 2022
Phase: N/A
Study type: Interventional

The purpose of the study is to determine feasibility of repetitive transcranial magnetic stimulation (rTMS) for individuals with moderate to severe cocaine or methamphetamine use disorder (CUD/MUD). Potential participants will be age 18-65, and interested in cutting down or stopping use. Participants will be randomized to one of two groups; groups will receive rTMS or sham rTMS (placebo) over the course of an 8-week treatment period, and complete follow-up assessments at the end of treatment, 12, and 16 weeks post-randomization.

NCT ID: NCT03266939 Active, not recruiting - Cocaine Dependence Clinical Trials

Rebalancing the Serotonergic System in Cocaine Dependence

Start date: October 4, 2018
Phase: Phase 1
Study type: Interventional

In the United States, 1.5 million people abuse cocaine leading to a host of negative health and economic consequences, yet no FDA approved treatment exists. To develop effective treatments, the following must be considered: 1) do potential medications ameliorate brain disruptions associated with cocaine use? 2) are multiple, targeted treatments necessary? To meet these goals, innovative multi-modal neuroimaging will be used to determine whether rebalancing the serotonergic (5-HT) system reduces cocaine cue reactivity, impulsivity, and normalizes related neurochemistry and brain connectivity.

NCT ID: NCT02037126 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Psilocybin-facilitated Treatment for Cocaine Use

Start date: May 2015
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to evaluate the feasibility and estimate the efficacy of psilocybin-facilitated treatment for cocaine use. We also will monitor the impact of psilocybin-facilitated treatment on the use of other drugs and outcomes relevant to cocaine involvement (e.g., criminal involvement). MRI assessment is a unique aspect of this study. As a potential biological mechanism of psilocybin's effect includes changes in default mode network functional connectivity (Carhart-Harris et al., 2012), we will determine if psilocybin's therapeutic effects are mediated by such changes. Moreover, as Glx (a brain metabolite that reflects glutamate) abnormalities have been shown to play a role in cocaine addiction, we will determine if psilocybin impacts Glx in the anterior cingulate cortex and hippocampus.

NCT ID: NCT00249691 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1

Start date: October 2005
Phase: Phase 3
Study type: Interventional

Although a great amount of research has been conducted to resolve cocaine dependence, an effective treatment has yet to be discovered. Topiramate is a drug that was found to be useful in treating alcohol dependence. The purpose of this study is to determine the effectiveness of topiramate in treating cocaine dependent individuals.

NCT ID: NCT00123383 Active, not recruiting - Cocaine Dependence Clinical Trials

Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence

Start date: July 2005
Phase: Phase 2
Study type: Interventional

The study aims to evaluate the safety and efficacy of modafinil (200 mg/day) over 10 weeks plus a tailored cognitive behavioural therapy program in the treatment of cocaine dependence.

NCT ID: NCT00100113 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1

Start date: June 2004
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.

NCT ID: NCT00094315 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1

Start date: September 2004
Phase: Phase 1
Study type: Interventional

To study of classical conditioning mechanisms associated with arousal, craving and cocaine use.

NCT ID: NCT00094289 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Interactions Between Cocaine and Ethanol and Disulfiram - 1

Start date: August 2004
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess potential interactions between intravenous cocaine and ethanol and oral disulfiram.

NCT ID: NCT00089687 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

GBR 12909 Study in Cocaine Experienced African American Volunteers - 1

Start date: April 2004
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess GBR 12909 in cocaine experienced African American Volunteers.

NCT ID: NCT00087750 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Interaction Between Cocaine and Quetiapine - 1

Start date: October 2003
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety of intravenous (IV) cocaine in subjects taking quetiapine at 3 dosage levels.