Substance-Related Disorders Clinical Trial
Official title:
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence: A [11C]-(+)-PHNO PET Investigation
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups. Dopamine release will be measured using PET neuroimaging with the radiotracer [11C]-(+)-PHNO.
SCIENTIFIC SUMMARY The project will, in a sample of cocaine-dependent (CD) and healthy
control (HC) subjects, use administration of Corticorelin, a synthetic form of corticotropin
releasing factor (CRF)and PET imaging to assess dopamine (DA) transmission in addiction. We
will use [11C]-(+)-PHNO PET to measure striatal DA receptor binding on two occasions: 1)
following corticorelin administration and 2) following saline. The change in receptor
binding between the two occasions (i.e., displacement of [11C]-(+)-PHNO by endogenous DA)
will index DA release.
SUBJECTS CD subjects will meet DSM-IV criteria for abuse or dependence and be ~10d cocaine
abstinent at the time of PET. HC will be recruited to match CD on age, sex, education, and
cigarette smoking.
PRIMARY OUTCOME MEASURES We will measure [11C]-(+)-PHNO binding on two occasions
(corticorelin, saline), with the difference between conditions indexing dopamine release;
this measure will then be compared between cocaine-dependent and control subjects. We will
also measure plasma cortisol and ACTH), physiological measures, and subjective craving and
mood.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
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