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Coagulopathies clinical trials

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NCT ID: NCT02345356 Completed - Atrial Fibrillation Clinical Trials

A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics

Start date: January 2016
Phase:
Study type: Observational

Caribbean Hispanics are a population with a disproportionately high prevalence of cardio-metabolic disorders but with a limited expectation of benefits from current pharmacogenetic algorithms derived mainly in subjects of relatively pure ancestry. The investigators focus on warfarin responses to develop urgently-needed DNA-driven prescription guidelines for this population, who have arisen from European, West African and Amerindian genomic origins to produce a highly heterogeneous population. Our project combines admixture analysis and DNA-sequencing with development of more accurate rules for better predictability of warfarin dosing to immediately serve this medically underserved population.